In Reply:‐We thank Dr. Jones for bringing his publication of 1963 to our attention. [1
] In that report, he observed that after the injection of 20 mg of gallamine into his right femoral artery, almost complete paralysis of the ipsilateral leg soon followed. The only other sign or subjective symptom of neuromuscular block that he experienced was ocular in nature, and these persisted for 2 h. It should be noted that the ED95
of gallamine is 2.4 mg/kg, and thus the dose he administered to himself was small. [2
] We certainly do not want to claim primacy for the observation that vision may be impaired by very small doses of nondepolarizing relaxants. It is a common observation that patients often complain of blurred vision after the usual d‐tubocurarine precurarizing dose of 0.05 mg/kg.
The only publications of Draper and Whitehead that we have been able to locate were done using a canine model. We would welcome any help in tracking down the citation of total body paralysis in humans to which Dr. Jones refers. Nonetheless, Dr. Jones is correct in stating that the observation that subjective symptoms of residual weakness may be long‐lasting is not a new one. A study that deserves to be read by all clinicians is the 1947 paper by Smith et al. [3
] In that report, Smith (an 80‐kg male) received 500 U (75 mg) of d‐tubocurarine over 33 min while fully awake. Despite the administration of 3.5 mg of neostigmine over the following 100 min (last dose, 4:30 P.M.), symptoms of residual weakness persisted throughout the evening.
Aaron F. Kopman, M.D.
Pamela S. Yee, B.A.
George G. Neuman, M.D.
Department of Anesthesiology; St. Vincent Hospital; Room NR408; 153 W. 11th Street; New York, New York 10011
(Accepted for publication August 21, 1997.)
1. Jones CS: Regional curarisation: Anaesthesia for surgery of the knee joint. Lancet 1963; 2:482-83.
2. Kopman AF: Pancuronium, gallamine and d-tubocurarine compared: Is speed of onset inversely related to drug potency? Anesthesiology 1989; 70:915-20.
3. Smith SS, Brown HO, Toman JEP, Goodman LS: The lack of cerebral effects of d-tubocurarine. Anesthesiology 1947; 8:1-14.
© 1997 American Society of Anesthesiologists, Inc.