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Anesthesiology:
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Thiopental Requirements for Induction of Anesthesia in Neonates and in Infants One to Six Months of Age.

Westrin, Per M.D.; Jonmarker, Christer M.D.; Werner, Olof M.D.

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Abstract

The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the patient breathed oxygen. Induction was considered satisfactory if there were no gross movements or coughing. The dose required for satisfactory induction in 50% of patients, ED50 (+/- SE), was 3.4 +/- 0.2 mg/kg in neonates and 6.3 +/- 0.7 mg/kg in infants (P < 0.001). It is concluded that the thiopental dose needed for satisfactory induction is less in neonates than in infants.
(C) 1989 American Society of Anesthesiologists, Inc.
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