Skip Navigation LinksHome > July 1989 - Volume 71 - Issue 1 > Epinephrine Increases the Effectiveness of Tetracaine Spinal...

Epinephrine Increases the Effectiveness of Tetracaine Spinal Anesthesia.

Carpenter, R. L. M.D.; Smith, H. S. M.D.; Bridenbaugh, L. D. M.D.

Collapse Box


The effect of epinephrine on the need for supplementation of spinal anesthesia produced with hyperbaric tetracaine was assessed in 60 patients undergoing transurethral resection of the prostate. Patients were randomly assigned to receive either 6 mg tetracaine alone (n = 20), 6 mg tetracaine with 0.2 mg epinephrine (n = 20), 10 mg tetracaine alone (n = 10), or 10 mg tetracaine with 0.2 mg epinephrine (n = 10). Observers were blinded to the presence or absence of epinephrine. Sensory level of anesthesia was assessed by pin prick, and surgery did not start until the level reached T10. Anesthesia was considered successful if the patient had no pain at the operative site. The success rate of low-dose tetracaine (6 mg) with epinephrine was 95% compared with 65% in patients receiving low-dose tetracaine alone (P = 0.04). All patients receiving 10 mg had successful anesthesia. Compared with patients receiving 6 mg tetracaine, those given 10 mg had higher dermatomal levels of anesthesia (P = 0.0001) and a higher incidence of nausea (P = 0.04). Thus, epinephrine can increase the effectiveness of low-dose tetracaine.
(C) 1989 American Society of Anesthesiologists, Inc.
Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.

Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.