Skip Navigation LinksHome > September/October 1966 - Volume 27 - Issue 5 > Nephrotoxicity Associated with Methoxyflurane Anesthesia.
Anesthesiology:
Original Article: PDF Only

Nephrotoxicity Associated with Methoxyflurane Anesthesia.

Crandell, Walter B. M.D.; Pappas, Stephen G. M.D.; Macdonald, Alastair

Collapse Box

Abstract

Among 94 cases in which methoxyflurane was used, 16 developed a toxic nephropathy characterized by diuresis. A seventeenth case which occurred 2 years previously in an affiliated hospital is also reported. Variations in the severity and duration of water loss modified the clinical features which, in which, well-defined cases, consisted of: urine volume of 2.5 to 4 liters per day with a negative fluid balance and pronounced weight loss for 6 to 10 days; elevation of serum sodium, chloride, osmolality and blood urea nitrogen; a relatively fixed urine specific gravity; urine osmolality in a range close to that of the serum and poorly responsive to a challenge test of fluid deprivation, rapid infusion and Pitressin. In most cases renal functional impairment was transient (10-20 days), but in 3 cases an elevated blood urea nitrogen remained 12, 16 and 29 months after onset.
(C) 1966 American Society of Anesthesiologists, Inc.
Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.
Login

Article Tools

Share