Fluroxene uptake in man was determined both at constant alveolar concentration (0.25 per cent) and at constant inspired concentration (0.5 per cent). Uptake at constant alveolar concentration rapidly fell from an initial value of 15 ml. per minute at the end of one minute to 5.3 ml. per minute after 10 minutes. At the end of 62 minutes, uptake was 3.4 ml. per minute. These experimental data correlate well with predicted theoretical values. Theoretical uptake at constant inspired concentration predicts an initial value of 22 ml. per minute with a constant decrease to 2.5 ml. per minute at 60 minutes. Experimentally measured values were about 50 per cent less in the first 10 minutes and about 25 per cent greater after 30 minutes.
(C) 1965 American Society of Anesthesiologists, Inc.