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Does Repeated Heat Sterilization of Local Anesthetic Drugs Affect Potency?.

Bridenbaugh, L. Donald M.D.; Moore, Daniel C. M.D.

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Abstract

Samples of all the commonly used local anesthetic drugs were autoclaved for periods varying from 30 minutes to 3 hours. These were subsequently assayed for potency. None of the drugs tested showed any appreciable loss of potency following autoclaving at 18 pounds pressure at 260-275 F. for 3 hours.
(C) 1964 American Society of Anesthesiologists, Inc.
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