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Anesthesia & Analgesia:
doi: 10.1213/ANE.0000000000000244
Cardiovascular Anesthesiology: Echo Rounds

Inferior Vena Cava Obstruction after Total Artificial Heart Implantation

Rehfeldt, Kent H. MD; Wittwer, Erica D. MD, PhD; Mauermann, William J. MD

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From the Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.

Accepted for publication January 24, 2014.

Funding: None.

The authors declare no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s web site.

Reprints will not be available from the authors.

Address correspondence to Kent H. Rehfeldt, MD, Department of Anesthesiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Address e-mail to rehfeldt.kent@mayo.edu.

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CASE PRESENTATION

A 51-year-old man with cardiac amyloidosis was admitted to the hospital with New York Heart Association class IV symptoms, requiring the initiation of epinephrine and milrinone infusions. Transthoracic echocardiography revealed thickened left ventricular walls with restrictive diastolic filling, a calculated ejection fraction of 13%, and severely reduced right ventricular systolic function. He was scheduled for implantation of a total artificial heart (TAH) (SynCardia Systems, Tucson, AZ) as a bridge to transplantation.

Intraoperative transesophageal echocardiography (TEE) before cardiopulmonary bypass confirmed severe biventricular systolic dysfunction and excluded intracardiac thrombus and patent foramen ovale. After TAH implantation, TEE was used to monitor air evacuation and ensure proper prosthetic valve function (Video 1, see Supplemental Digital Content 1, http://links.lww.com/AA/A899). A midesophageal (ME) bicaval view, modified by slight probe advancement, was used to verify unimpeded inferior vena cava (IVC) flow (Fig. 1, A–C, Video 1, see Supplemental Digital Content 1, http://links.lww.com/AA/A899). Likewise, a ME 2-chamber view with leftward and rightward rotation confirmed normal pulmonary vein (PV) flow velocities. With sternal closure, there was a reduction in TAH flow from 6.7 to 3.9 L/min. TEE examination again showed normal PV velocities. However, the IVC near its junction with the right atrium (RA) was narrowed by a tissue infolding to a luminal diameter of 0.5 cm, and color flow acceleration was apparent (Fig. 2, A–B, Video 2, see Supplemental Digital Content 2, http://links.lww.com/AA/A900). Spectral Doppler interrogation of flow entering the RA from the IVC revealed a peak velocity of 140 cm/s (Fig. 2C). The sternum was reopened, and the surgeon placed a suture to anchor the driveline to the left chest wall, resulting in overall leftward and anterior device displacement. Subsequently, the proximal IVC diameter increased to 1.7 cm with laminar color flow (Video 3, see Supplemental Digital Content 3, http://links.lww.com/AA/A901). Blood velocity entering the RA from the IVC decreased to 74 cm/s. The sternum was again closed, this time with TAH flow maintained at 6.8 L/min and no TEE evidence of venous flow obstruction. The patient provided consent for publication.

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DISCUSSION

Clinical use of the SynCardia TAH continues to increase with >1200 devices implanted worldwide. Unlike axial flow left ventricular assist devices that do not provide direct right heart support, the TAH may be selected for patients with severe biventricular dysfunction and is approved in the United States both as a bridge to transplantation and as destination therapy. The history, indications, technical aspects, and general applications of TEE during TAH implantation have recently been reviewed.1–4

Clinicians have recognized venous inflow obstruction after TAH implantation for more than a decade.5 Copeland et al.6 noted that 6 of 62 patients had unspecified “fit problems,” and 4 required reoperation to reposition the device. Compression or kinking of the IVC and PVs may occur at the time of implantation or with sternal closure.2 Should venous compression be noted, the surgeon may elect to place a suture around the neoventricle or driveline and anchor it to the left chest wall to improve venous inflow. By pulling the rigid right neoventricle leftward and anterior and away from the IVC, direct compression or torquing of this relatively low-pressure, venous structure can be ameliorated (Fig. 3). Most devices currently in use have a maximum stroke volume of 70 cc and a total device volume of 750 cc.2 In an attempt to prevent fit problems and compression of venous structures, patient selection criteria for TAH implantation have traditionally included a body surface area greater than 1.7 m2. However, a smaller version of the TAH has recently been developed and may reduce the occurrence of venous obstruction.

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Although often mentioned in general terms,1–6 to our knowledge, this is the first specific report detailing the TEE findings of IVC obstruction after TAH implantation. Normal IVC diameter is 1.2 to 1.7 cm.7 However, normal IVC blood velocity during positive pressure ventilation as measured by TEE has not been well described. In healthy, spontaneously breathing volunteers, a peak resting IVC velocity ranging from 30 to 45 cm/s has been measured by invasive catheter.8 This same study found a significant increase in IVC velocity with exercise, with values as high as 147 cm/s.8 Typical IVC velocity after TAH insertion has not been reported. TEE imaging of the IVC after TAH insertion may be accomplished using a modified ME bicaval view with slight probe advancement. In this view, the IVC is relatively perpendicular to the ultrasound beam, affording the opportunity to measure diameter though less ideal for velocity determination. In our case, the angle of blood flow entering the RA from the IVC was such that reasonable Doppler alignment was possible. After device repositioning, IVC inflow velocity decreased by approximately 50%, while the diameter more than doubled. Although there are no specific criteria to diagnose IVC obstruction in this setting, the combination of an unexpectedly small diameter, flow acceleration by color Doppler, and blood velocities in the range of 100 cm/s may suggest the need for intervention. In addition to flow acceleration at the site of obstruction, IVC dilation and reduced flow proximal to the stenosis may also be noted.7 This may manifest as monophasic hepatic vein flow with peak velocities <40 cm/s as demonstrated by pulsed-wave Doppler.7

Sharma et al.7 recently reported a case in which IVC obstruction was noted by TEE postoperatively in a patient who had recently undergone mitral valve replacement. As in our case, an area of luminal narrowing at the RA-IVC junction was identified along with peak velocities exceeding 100 cm/s.7 In contrast to Sharma et al.,7 we did not interrogate hepatic vein flow or specifically document prestenotic IVC dilation, because the findings of IVC narrowing and flow acceleration on sternal closure obviously differed from presternal closure values. In the case presented by Sharma et al.,7 deep suture placement was ultimately found to be the cause of IVC obstruction although others have noted this complication in the setting of heart or liver transplantation.7

While normal in this case, PV flow should be carefully examined after TAH insertion, ideally comparing findings with preinsertion values. A variety of imaging planes and probe movements may be used to visualize the PVs. Echocardiographers are familiar with PV velocity assessment with peak values expected in the 30 to 60 cm/s range with characteristic systolic, diastolic, and atrial reversal flow patterns.2 E

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Clinicians Key Teaching Points

By Nikolaos J. Skubas, MD, Roman M. Sniecinski, MD, and Martin J. London, MD

* Evaluation of the patency of the inferior vena cava (IVC) and superior vena cava should be performed both before and after placement of a total artificial heart (TAH). This is commonly done using the midesophageal bicaval view, in which the diameters of the IVC and superior vena cava can be measured. Color flow Doppler can distinguish turbulent from laminar flow, although absolute velocities cannot be determined since flow from both cava is perpendicular to the ultrasound beam.

* Other considerations before implanting a TAH include excluding any interatrial communications, such as a patent foramen ovale, which can also be done using the midesophageal bicaval view. After implantation, transesophageal echocardiography can evaluate intracardiac de-airing, as well as the function of the TAH prosthetic heart valves.

* In this case, the TAH flow decreased by 50% immediately after chest closure due to compression of the IVC at the RA junction. This was diagnosed by a decreased IVC diameter and flow acceleration on color flow Doppler. The compression was relieved by anchoring the TAH away from the IVC.

* When poor TAH output is encountered, a narrowing in diameter of the IVC (normal: 1.2–1.7 cm), and turbulent flow by color flow Doppler should raise suspicion of IVC obstruction.

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DISCLOSURES

Name: Kent H. Rehfeldt, MD.

Contribution: This author helped write and edit the manuscript.

Attestation: Kent H. Rehfeldt approved the final manuscript.

Name: Erica D. Wittwer, MD, PhD.

Contribution: This author helped write and edit the manuscript.

Attestation: Erica D. Wittwer approved the final manuscript

Name: William J. Mauermann, MD.

Contribution: This author helped write and edit the manuscript.

Attestation: William J. Mauermann approved the final manuscript.

This manuscript was handled by: Martin J. London, MD.

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REFERENCES

1. Sale SM, Smedira NG. Total artificial heart. Best Pract Res Clin Anaesthesiol. 2012;26:147–65

2. Gaitan BD, Thunberg CA, Stansbury LG, Jaroszewski DE, Arabia FA, Griffith BP, Grigore AM. Development, current status, and anesthetic management of the implanted artificial heart. J Cardiothorac Vasc Anesth. 2011;25:1179–92

3. Kasirajan V, Tang DG, Katlaps GJ, Shah KB. The total artificial heart for biventricular heart failure and beyond. Curr Opin Cardiol. 2012;27:301–7

4. Mizuguchi KA, Padera RF Jr, Kowalczyk A, Doran MN, Couper GS, Fox AA. Transesophageal echocardiography imaging of the total artificial heart. Anesth Analg. 2013;117:780–4

5. Arabia FA, Copeland JG, Pavie A, Smith RG. Implantation technique for the CardioWest total artificial heart. Ann Thorac Surg. 1999;68:698–704

6. Copeland JG, Smith RG, Arabia FA, Nolan PE, McClellan D, Tsau PH, Sethi GK, Bose RK, Banchy ME, Covington DL, Slepian MJ. Total artificial heart bridge to transplantation: a 9-year experience with 62 patients. J Heart Lung Transplant. 2004;23:823–31

7. Sharma V, Wasowicz M, Brister S, Karski J, Meineri M. Postoperative transesophageal echocardiography diagnosis of inferior vena cava obstruction after mitral valve replacement. Anesth Analg. 2011;113:1343–6

8. Wexler L, Bergel DH, Gabe IT, Makin GS, Mills CJ. Velocity of blood flow in normal human venae cavae. Circ Res. 1968;23:349–59

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