Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have
no recent searches
You currently have no recent searches
Weinberg, Guy MD; Hoffman, William PhD; Feinstein, Douglas PhD; Paisanthasan, Chanannait MD
Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, email@example.com.
We thank Dr. Coleman for his thoughtful comments on our article (1) describing the ability of bupivacaine to retard myocardial acidosis during ventricular fibrillation. We agree that “inhibition of cellular metabolism” per se is an incomplete explanation, and identifying the precise molecular mechanisms of this phenomenon is a current focus of our laboratory. However, we question Dr. Coleman’s explanation that vasodilation and inhibition of capillary fibrin cuffs contribute significantly to the effect. If bupivacaine improved tissue perfusion and oxygen delivery, one would expect higher myocardial oxygen tension in those animals. We found the opposite: tissue PmO2, which is closely related to capillary perfusion, was depleted rapidly in all bupivacaine-treated animals. This observation is also consistent with the well-known uncoupling effect of bupivacaine that Dr. Coleman mentions (2,3). Uncoupling oxidative phosphorylation from mitochondrial respiration increases oxygen consumption but reduces ATP production, an effect consistent with a net inhibition of cellular metabolism.
Guy Weinberg, MD
William Hoffman, PhD
Douglas Feinstein, PhD
Chanannait Paisanthasan, MD
Department of Anesthesiology
University of Illinois at Chicago
© 2004 International Anesthesia Research Society
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Anesthesia & Analgesia.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Need to Activate a New Subscription?Recently purchased a subscription? Login or Register a new account
and enter your subscription ID, or Subscribe Now!
Become a Society Member
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in for
days or until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection