Anesthesia & Analgesia:
Intravenous Lidocaine for Ambulatory Anesthesia: Good to Go or Not So Fast?
Wu, Christopher L. MD*; Liu, Spencer S. MD†
From the *Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland; and †Department of Anesthesiology, Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York, New York.
Accepted for publication August 3, 2009.
Supported by the Department of Anesthesiology, Hospital for Special Surgery, New York, NY.
Reprints will not be available from the author.
Address correspondence to Spencer S. Liu, MD, Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th St., New York, NY 10021. Address e-mail to firstname.lastname@example.org.
In this issue of the journal, McKay et al.1 report the results of randomizing patients undergoing ambulatory surgery to an IV infusion of lidocaine or saline. Although rarely used as a component of ambulatory anesthesia, perioperative infusion of IV lidocaine is attractive. Low-dose IV lidocaine is easy to administer, has well-established analgesic,2 antihyperalgesic, and antiinflammatory effects,3 and has minimal toxicity in commonly studied doses (typically 1.5–3 mg · kg−1 · h−1).2 Researchers examining infusion of IV lidocaine for various major abdominal procedures in previous randomized controlled trials reported quite favorable effects that have been summarized in a recent meta-analysis.2 Use of lidocaine significantly reduced the incidence of nausea and vomiting (32% vs 52%), marginally reduced pain scores (−5/100 mm visual analog scale), and decreased duration of postoperative ileus (−8.4 h) and hospital stay (−0.84 days). These are impressive results from a simple intervention and compare favorably with the effects from the more technically cumbersome and expensive use of epidural analgesia.4 Thus, it makes sense to investigate whether such positive outcomes from IV lidocaine can be transported to the field of ambulatory anesthesia. Currently, most surgeries in the United States are performed on an ambulatory basis (60% of all procedures in 2007),5 and an inexpensive, technically simple, and time-limited intervention that provides long-lasting benefit would be valuable.
However, the effects of IV lidocaine in this study were much less gratifying than previously reported for major abdominal surgery. Opioid consumption was reduced but without affecting the incidence of opioid-related side effects, such as nausea and vomiting. Pain scores were temporarily reduced in the postoperative care unit but only for a few hours. Finally, length of stay was not affected. Why would lidocaine not demonstrate greater efficacy? Part of the reason may be attributable to the proposed mechanism for the effects of low-dose IV infusions of lidocaine for perioperative analgesia. It is speculated that sodium channel block by lidocaine plays a minor role, whereas suppression of the inflammatory process may have accounted for the reduction in ileus and hospital stay after major abdominal surgery.2,3 Previous studies have observed much greater blood levels of inflammatory mediators after major abdominal surgery versus less extensive procedures.6 For example, pancreatoduodenectomy resulted in dramatic increases in inflammatory mediators (e.g., tumor necrosis factor-α and interleukin-6) that are not suppressed by epidural anesthesia, whereas hip replacement surgery did not result in increases in these mediators. Martin et al.,7 who conducted a recent study examining perioperative IV infusion of lidocaine versus saline in patients undergoing total hip replacement, did not report any effects on pain, opioid-sparing, or postoperative rehabilitation with lidocaine. Thus, it may simply be that most ambulatory surgical procedures are too minimally invasive to benefit from IV infusion of lidocaine. Another key consideration is that, by simply transferring the usual outcome measurements (e.g., length of stay) for hospitalized patients to ambulatory anesthesia studies, we are simply looking at the wrong outcomes.5,8
There is increasing interest in patient-reported outcomes8 such as quality of life, postoperative quality of recovery, and patient satisfaction. This reflects the increased consumer orientation of health care9 and may be especially important in ambulatory surgery.10 Evaluating patient-reported outcomes may seem intuitively simple; however, the proper psychometric development of a validated instrument with appropriate responsiveness for the intended setting is not an easy task,11 and there is a paucity of validated instruments available for use after anesthesia. A recent systematic review11 found only 1 instrument, the quality of recovery (QoR)-40,12 that fulfilled the 8 criteria of appropriateness, reliability, validity, responsiveness, precision, interpretability, acceptability, and feasibility. Furthermore, the QoR-40 may not be optimal for the assessment of recovery after ambulatory anesthesia. The majority of studies utilizing the QoR-40 were performed in inpatients rather than outpatients because this instrument was not designed for use in ambulatory surgical patients. An abbreviated version of the QoR-40 is available13 and may be less burdensome to administer for patients undergoing ambulatory surgery.11 Future studies examining interventions in ambulatory anesthesia should consider assessing both patient-reported outcomes and postdischarge symptoms. By examining these issues in a comprehensive fashion, anesthesiologists will further develop their role as the perioperative physician in the arena of ambulatory surgery.14
1. McKay A, Gottschalk A, Ploppa A, Durieux ME, Groves DS. Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery. Anesth Analg 2009;109:1805–8
2. Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg 2008;95:1331–8
3. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology 2000;93:858–75
4. Liu SS, Wu CL. Effect of postoperative analgesia on major postoperative complications: a systematic update of the evidence. Anesth Analg 2007;104:689–702
5. Chanthong P, Abrishami A, Wong J, Herrera F, Chung F. Systematic review of questionnaires measuring patient satisfaction in ambulatory anesthesia. Anesthesiology 2009;110:1061–7
6. Naito Y, Tamai S, Shingu K, Shindo K, Matsui T, Segawa H, Nakai Y, Mori K. Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology 1992;77:426–31
7. Martin F, Cherif K, Gentili ME, Enel D, Abe E, Alvarez JC, Mazoit JX, Chauvin M, Bouhassira D, Fletcher D. Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty. Anesthesiology 2008;109:118–23
8. Liu SS, Wu CL. The effect of analgesic technique on postoperative patient-reported outcomes including analgesia: a systematic review. Anesth Analg 2007;105:789–808
9. Macario A, Vasanawala A. Improving quality of anesthesia care: opportunities for the new decade. Can J Anaesth 2001;48:6–11
10. Wu CL, Berenholtz SM, Pronovost PJ, Fleisher LA. Systematic review and analysis of postdischarge symptoms after outpatient surgery. Anesthesiology 2002;96:994–1003
11. Herrera FJ, Wong J, Chung F. A systematic review of postoperative recovery outcomes measurements after ambulatory surgery. Anesth Analg 2007;105:63–9
12. Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth 2000;84:11–5
13. Myles PS, Hunt JO, Nightingale CE, Fletcher H, Beh T, Tanil D, Nagy A, Rubinstein A, Ponsford JL. Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults. Anesth Analg 1999;88:83–90
14. White PF, Kehlet H, Neal JM, Schricker T, Carr DB, Carli F. The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care. Anesth Analg 2007;104:1380–96
© 2009 International Anesthesia Research Society