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A Novel Device for the Evaluation of Hemostatic Function in Critical Care Settings

Ferrante, Elisa A. PhD; Blasier, Kiev R. MS; Givens, Thomas B. MS; Lloyd, Cynthia A. PhD; Fischer, Timothy J. BS; Viola, Francesco PhD

doi: 10.1213/ANE.0000000000001413
Hemostasis: Brief Report

Major surgical procedures often result in significant intra- and postoperative bleeding. The ability to identify the cause of the bleeding has the potential to reduce the transfusion of blood products and improve patient care. We present a novel device, the Quantra Hemostasis Analyzer, which has been designed for automated, rapid, near-patient monitoring of hemostasis. The Quantra is based on Sonic Estimation of Elasticity via Resonance Sonorheometry, a proprietary technology that uses ultrasound to measure clot time and clot stiffness from changes in viscoelastic properties of whole blood during coagulation. We present results of internal validation and analytical performance testing of the technology and demonstrate the ability to characterize the key functional components of hemostasis.

Published ahead of print May 24, 2016.

From *HemoSonics LLC, Charlottesville, Virginia; and University of Virginia, Charlottesville, Virginia.

Published ahead of print May 24, 2016.

Accepted for publication April 15, 2016.

Funding: This work was supported by grant R44HL103030 from the National Heart, Lung, and Blood Institute of the NIH and by the investors of HemoSonics LLC.

Conflict of Interest: See Disclosures at the end of the article.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website.

Reprints will not be available from the authors.

Address correspondence to Francesco Viola, PhD, HemoSonics LLC, 400 Preston Ave., Suite 250, Charlottesville, VA 22903. Address e-mail to fviola@hemosonics.com.

© 2016 International Anesthesia Research Society
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