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Neurologic Injury With Severe Adult Respiratory Distress Syndrome in Patients Undergoing Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Analysis

Klinzing, Stephanie MD*; Wenger, Urs MD; Stretti, Federica MD*‡; Steiger, Peter MD*; Rushing, Elisabeth J. MD§; Schwarz, Urs MD; Maggiorini, Marco MD

doi: 10.1213/ANE.0000000000002431
Critical Care and Resuscitation: Brief Report

This retrospective single-center study investigated the incidence of neurologic injury as determined by autopsy or cerebral imaging in 74 patients undergoing extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome. Seventy-three percent of patients were treated with venovenous and 27% with venoarterial ECMO. ECMO-associated intracerebral hemorrhage was diagnosed in 10.8% of patients. There were no cases of ischemic stroke. Clinical characteristics did not differ between patients with and without neurologic injury. Six-month survival was 13% (Wilson confidence interval, 2%–47%) in patients with severe intracerebral hemorrhage compared to an overall survival rate of 57% (Wilson confidence interval, 45%–67%).

Published ahead of print August 31, 2017.

From the *Surgical Intensive Care Unit and Medical Intensive Care Unit, University Hospital of Zurich, Zurich, Switzerland; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy; and Departments of §Neuropathology and Neurology, University Hospital of Zurich, Zurich, Switzerland.

Accepted for publication July 13, 2017.

Published ahead of print August 31, 2017.

Funding: None.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Stephanie Klinzing, MD, Surgical Intensive Care Unit, University Hospital of Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland. Address e-mail to Stephanie.klinzing@usz.ch.

© 2017 International Anesthesia Research Society
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