Attenuation of Regional Cerebral Blood Flow During Memory Processing After Coronary Artery Bypass Surgery

Badgaiyan, Rajendra D. MD*; Weise, Steven BS; Wack, David S. PhD; Vidal Melo, Marcos F. MD, PhD§

doi: 10.1213/ANE.0000000000000334
Cardiovascular Anesthesiology: Brief Report

Reports of memory impairment after cardiac surgery are controversial. To address this controversy, we used positron emission tomography to examine changes in regional cerebral blood flow (rCBF) during memory processing before and after elective coronary artery bypass grafting surgery. In postoperative scans, we observed significantly reduced rCBF in 2 of the most important memory processing areas: the medial temporal lobe (P = 0.023) and the prefrontal cortex (P = 0.002). The results suggest postoperative attenuation of rCBF in brain areas involved in memory processing. These reductions could be used to evaluate severity of memory impairment after coronary artery bypass grafting surgery in patients at risk.

Published ahead of print June 23, 2014.

From the *Department of Psychiatry, State University of New York at Buffalo, Buffalo, New York; †Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts; ‡Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, New York; and §Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Published ahead of print June 23, 2014.

Accepted for publication May 1, 2014.

Funding: This study was funded by a grant of the Society of Cardiovascular Anesthesiologists to Dr. Vidal Melo.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Marcos F. Vidal Melo, MD, PhD, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114. Address e-mail to VidalMelo.Marcos@mgh.harvard.edu.

© 2014 International Anesthesia Research Society