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Prolonged Opioid Use After Knee Arthroscopy in Military Veterans

Rozet, Irene MD*†; Nishio, Isuta MD, PhD*†; Robbertze, Reinette MBChB, FANZCA*; Rotter, Douglas BS, JD; Chansky, Howard MD; Hernandez, Adrian V. MD, PhD

doi: 10.1213/ANE.0000000000000292
Pain Medicine: Research Report

BACKGROUND: Chronic postoperative pain occurs with an appreciable incidence after elective surgery. Known risk factors include perioperative pain and posttraumatic stress disorder (PTSD). Military veterans are a population at particular risk for PTSD and hence may be at increased risk for chronic pain after surgery. Our goal was to identify risk factors for chronic postoperative pain in young veterans after minor elective surgery, including the contribution of PTSD.

METHODS: We reviewed the medical and pharmacy records of veterans (18–50 years old), undergoing elective knee arthroscopy from 2007 to 2010 at the Veteran’s Administration Puget Sound Health Care System. The data included demographics, ASA physical status class, comorbidities, anesthesia medications, and opioid prescriptions starting 3.5 months before surgery and ending 3.5 months after surgery. We documented the presence of PTSD based on either the patient’s problem list or the clinical notes. We used prolonged postoperative opioid prescription longer than 3 months after surgery as a surrogate for chronic postoperative pain.

RESULTS: We identified 145 patients who met inclusion criteria. The median age was 39 ± 8 years old. Eighty-seven percent of the patients were men. The prevalence of PTSD was 32% (95% confidence interval, 25%–41%). PTSD was associated with increased incidence of smoking (P = 0.009) and preoperative opioid use (P = 0.0006). Preoperative opioids were prescribed in 44% (63 of 145) of the patients: in 64% (30 of 47) of patients with PTSD, compared with 34% (33 of 98) in patients without PTSD (P = .0006). Chronic postoperative pain was identified in 30% (43 of 145) of patients. The strongest independent predictor of chronic postoperative pain was an opioid prescription before surgery (odds ratio = 65.3; 95% confidence interval, 014.5–293.0). In patients older than 27.5 years who did not receive opioids before surgery, PTSD may also have been a risk factor for chronic postoperative pain.

CONCLUSIONS: This single-center retrospective study suggests that the most important predictor of chronic postoperative pain is preoperative opioid use. For patients not taking opioids preoperatively, PTSD may increase the risk of prolonged postoperative opioid prescriptions and chronic postoperative pain, potentially related to patient age.

Published ahead of print June 23, 2014.

From the *Department of Anesthesiology and Pain Medicine, University of Washington; Department of Veterans Affairs, Puget Sound Health Care System, Seattle, Washington; and Department of Quantitative Health Sciences, Health Outcomes and Clinical Epidemiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Accepted for publication March 13, 2014.

Published ahead of print June 23, 2014.

Funding: None.

The authors declare no conflicts of interest.

Reprints will not be available from the authors.

Address correspondence to Irene Rozet, MD, Department of Anesthesiology and Pain Medicine, University of Washington; Department of Veterans Affairs, Puget Sound Health Care System, ANES-112, 1660 S Columbian Way, Seattle, WA, 98015. Address e-mail to

© 2014 International Anesthesia Research Society