Anesthesia & Analgesia

Skip Navigation LinksHome > May 2014 - Volume 118 - Issue 5 > TEG® Functional Fibrinogen Analysis May Overestimate Fibrino...
Anesthesia & Analgesia:
doi: 10.1213/ANE.0000000000000172
Cardiovascular Anesthesiology: Brief Report

TEG® Functional Fibrinogen Analysis May Overestimate Fibrinogen Levels

Ågren, Anna MD, PhD*†; Wikman, Agneta Taune MD, PhD‡§; Östlund, Anders MD, PhD; Edgren, Gustaf MD, PhD¶*

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Fibrinogen is of crucial importance in patients with ongoing bleeding. In this study, we compared fibrinogen concentration measured by thrombelastography (TEG®) with fibrinogen plasma concentration determined by Clauss. Sixty-three surgical patients and 38 healthy controls were included. For the whole group (patients and controls, n = 101), TEG® functional fibrinogen was on average 1.0 g/L higher than the plasma fibrinogen concentration (3.5 vs 2.5 g/L, 95% confidence interval for difference 0.8 to 1.2 g/L, P < 0.0001). Similar patterns were observed when patients and healthy controls were analysed separately. The fibrinogen level may be overestimated when assessed using TEG® compared with the fibrinogen plasma concentration measured by the conventional method.

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