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Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia

Soeding, Peter MD*; Deppe, Matthias*; Gehring, Hartmut MD, PhD*

doi: 10.1213/ANE.0b013e3181eb6239
Analgesia: Brief Report

BACKGROUND: The Masimo Radical 7® is a new pulse CO oximeter designed to measure methemoglobin. The device has not been evaluated in a clinical setting.

METHODS: In this prospective observational study we compared the arterial methemoglobin levels and the corresponding pulse CO-oximetric values of the Radical 7® in regional anesthesia with prilocaine.

RESULTS: We analyzed 360 data pairs with methemoglobin values up to 6.6%. The mean bias and limits (±1.96 SD) of the device were 0.27% (±1.33%).

CONCLUSION: We found a high degree of agreement in measurement of methemoglobin between the 2 methods.

Published ahead of print August 12, 2010

From the *Department of Anesthesiology, University Clinic of Schleswig— Holstein, Campus Luebeck, Luebeck, Germany.

Parts of the work were presented at the 2008 American Society of Anesthesiologists annual meeting in Baltimore, Maryland, and at the 2008 European Society of Anesthesiologists annual meeting in Copenhagen, Denmark.

Address correspondence to Peter Soeding, MD, Department of Anesthesiology, University Clinic of Schleswig—Holstein, Campus Luebeck, Ratzeburger Allee 160, D-23,538 Luebeck, Germany. Address e-mail to

Accepted June 1, 2010

Published ahead of print August 12, 2010

© 2010 International Anesthesia Research Society
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