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The Effects of the Menstrual Cycle on the Hemodynamic Response to Laryngoscopy and Tracheal Intubation

Hanc, Volkan MD; Yurtlu, Serhan MD*; Hakimoğlu, Sedat MD*; Ylmaz, Mensure MD†ı; Ayoğlu, Hilal MD*; Başaran, Mustafa MD; Erdoğan, Gülay MD*; Okyay, Rahşan Dilek MD*; Turan, Işl Özkoçak MD

doi: 10.1213/ANE.0b013e3181e62984
Ambulatory Anesthesiology: Brief Report

We designed this study to determine the effect of the menstrual cycle on the hemodynamic response to tracheal intubation (TI). Sixty-two ASA I women who were either in the follicular phase (group F, n = 31) or luteal phase (group L, n = 31) of their menstrual cycle were included in the study. Patients received propofol and rocuronium for intubation. Hemodynamic variables were recorded before administration of the IV anesthetic, as well as after TI. Rate pressure products were calculated. Groups were similar in terms of demographic data. Rate pressure products values at the first minute after TI were significantly increased in group L than were those in group F (P < 0.001). We conclude that the phase of the menstrual cycle is an important factor in the hemodynamic response to TI.

Published ahead of print June 28, 2010

From the *Department of Anesthesiology and Reanimation, School of Medicine, Zonguldak Karaelmas University; Department of Anesthesiology and Reanimation, Rize State Hospital; and Department of Gynaecology and Obstetric, School of Medicine, Zonguldak Karaelmas University.

Reprints are available from Serhan Yurtlu, MD, Tıp Fakültesi, Zonguldak Karaelmas Universitesi Hastanesi, C Blok Merkezi Ameliyathane, Kat: 3, Esentepe/Kozlu, Zonguldak, Turkey. E-mail:

Address correspondence to Volkan Hancı, MD, Tepebaçsı Mahallesi, Yapkent Sokak, A13 Blok. Kat: 5, Daire: 10, Zonguldak, Turkey. Address e-mail to

Accepted April 25, 2010

Published ahead of print June 28, 2010

© 2010 International Anesthesia Research Society