Anesthesia & Analgesia

Skip Navigation LinksHome > August 2005 - Volume 101 - Issue 2 > A Prospective, Randomized, Double-Blind, Placebo-Controlled...
Anesthesia & Analgesia:
doi: 10.1213/01.ANE.0000155286.20467.28
Anesthetic Pharmacology: Brief Report

A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers

Kwok, Yung FHKCA*; Ng, Kwok F. J. FANZCA†; Li, Carina C. F. FANZCA*; Lam, Clarence C. K. MRCPath‡; Man, Ricky Y. K. PhD§

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Ganoderma lucidum is a Chinese herbal medicine popular with cancer patients. Previous in vitro studies suggested that Ganoderma lucidum might impair hemostasis. In this prospective, randomized double-blind study, healthy volunteers received orally Ganoderma lucidum capsules 1.5 g (n = 20) or placebo (n = 20) daily for 4 wk. We monitored subjects before drug administration and at 4 and 8 wk thereafter by routine coagulation screen, fibrinogen concentration, von Willebrand ristocetin cofactor activity, platelet function analyzer PFA-100®, and thrombelastography. There were no significant between-group differences and all measurements remained within the normal range. Ganoderma lucidum ingestion over 4 wk was not associated with impairment of hemostasis.

© 2005 International Anesthesia Research Society


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