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Brain Sodium, Potassium, and Osmolality: Effects on Anesthetic Requirement

TANIFUJI, YASUMASA M.D.; EGER, EDMOND I. M.D.
Anesthesia & Analgesia: July-August 1978
SCIENTIFIC ARTICLE: PDF Only

We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypoosmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodiunl and osmolality. MAC c-ncomitantly increased 43%. Serum hyperosmolality achieved by administration of 12 and 25% dextrose increased cerebrospinal fluid osmolality without appreciably altering cerebrospinal fluid sodium or MAC. Infusion of 5% dextrose produced hypo-osmolaiity of blood and cerebrospinal fluid. Cerebrospinal fluid sodium was diluted and MAC was reduced by-24%.

Supported by USPHS GM 15571. the Foundation for In Service Training and Welfare of the Private School Personnel in Japan, and by a grant from the Anesthesia Research Foundation

© 1978 International Anesthesia Research Society