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Systemic Lupus Erythematosusassociated Neutrophilic Dermatosis: A Review and Update

Larson, Allison R. MD; Granter, Scott R. MD

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0000000000000026
Review Articles
Abstract

Neutrophilic dermatoses are a rare manifestation of systemic lupus erythematosus (SLE). In recent years, a growing body of literature describes a pathologic spectrum of neutrophilic infiltrates that may be seen in lupus patients. It is particularly important to recognize that neutrophilic dermatoses can be the initial manifestation of SLE in a third of patients. We were able to identify 47 patients with SLE associated with neutrophilic tissue reactions. In this review, we describe the histologic and clinical features of these cases in the hope that increased awareness of this unusual manifestation of SLE will generate prompt diagnosis and improved patient care.

Author Information

Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston MA

The authors have no funding or conflicts of interest to disclose.

Reprints: Scott R. Granter, MD, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St. J-820, Jimmy Fund Building, Boston, MA 02115 (e-mail: sgranter@partners.org).

© 2014 by Lippincott Williams & Wilkins.