Skip Navigation LinksHome > January 2014 - Volume 21 - Issue 1 > Innovative Therapies in Ewing Sarcoma
Advances in Anatomic Pathology:
doi: 10.1097/PAP.0000000000000003
Review Articles

Innovative Therapies in Ewing Sarcoma

Amaral, Ana Teresa BSc*; Ordóñez, José Luis PhD*; Otero-Motta, Ana Pastora PhD*; García-Domínguez, Daniel J. PhD*; Sevillano, María Victoria MLT*; de Álava, Enrique MD, PhD*,†

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Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of new therapeutic targets, many questions still remain open. In this review we focus on the research on targeted therapies in this malignancy, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research.

© 2014 by Lippincott Williams & Wilkins.


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