Skip Navigation LinksHome > November 2013 - Volume 20 - Issue 6 > Identifying Lynch Syndrome in Patients With Ovarian Carcinom...
Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e3182a92cf8
Review Articles

Identifying Lynch Syndrome in Patients With Ovarian Carcinoma: The Significance of Tumor Subtype

Chui, Michael Herman MD*; Gilks, C. Blake MD, FRCPC; Cooper, Kumaresan MD, DPhil, FRCPath; Clarke, Blaise A. MBBCh, FRCPC*,§

Collapse Box

Abstract

Up to 15% of ovarian cancers are etiologically linked with hereditary susceptibility. Within this group, germline mutations in mismatch repair (MMR) genes, known otherwise as Lynch syndrome (LS), account for the majority of cases that are not associated with mutations in BRCA1 or BRCA2. Clinical schemas specific for gynecologic cancers have been developed to identify patients with LS; however, many of the recommendations are poorly defined. Few case series of germline-confirmed LS-associated ovarian cancers have been reported, limited by small sample size and often lacking central pathology review. Much insight has been gained from studies of unselected cohorts, using immunohistochemical assessment of MMR protein expression or microsatellite instability analysis. In spite of contradictory results, likely reflective of differences in study design, sample size and methodology, a recurring observation is the overrepresentation of “endometriosis-associated tumors,” namely, endometrioid and clear cell subtypes, in the group of ovarian tumors with MMR deficiency. In this review, we summarize the clinical and histomorphologic features of LS-associated/MMR-deficient ovarian epithelial cancers and recommend that reflex testing be performed on the basis of tumor subtype.

Copyright © 2013 by Lippincott Williams & Wilkins

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.