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Value of GATA3 Immunostaining in Tumor Diagnosis: A Review

Ordóñez, Nelson G. MD

doi: 10.1097/PAP.0b013e3182a28a68
New Antibody/Techniques

GATA3 is a member of a group of zinc-finger transcription factors that is involved in cell development and differentiation. Recent studies have shown that, among tumors, GATA3 is commonly expressed in both urothelial tumors and breast epithelial neoplasms. With the exception of salivary gland and parathyroid tumors, GATA3 has been reported to be either absent or only rarely expressed in other epithelial tumors. Owing to its restricted expression in urothelial and breast carcinomas, GATA3 has proved to be a useful immunohistochemical marker for assisting in distinguishing these 2 groups of neoplasms from other malignancies with which they may be confused.

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX

The authors have no funding or conflicts of interest to disclose.

Reprints: Nelson G. Ordóñez, MD, Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (e-mail: nordonez@mdanderson.org).

© 2013 by Lippincott Williams & Wilkins.