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Value of SOX10 Immunostaining in Tumor Diagnosis

Ordóñez, Nelson G. MD

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e318297a9d0
New Antibody/Techniques
Abstract

SOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiation, and some salivary gland neoplasms, particularly those with myoepithelial differentiation. Because of its restricted expression, SOX10 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which are briefly reviewed.

Author Information

Department of Pathology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX

The author has no funding or conflicts of interest to disclose.

Reprints: Nelson G. Ordóñez, MD, Department of Pathology, M.D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: nordonez@mdanderson.org).

© 2013 by Lippincott Williams & Wilkins.