Skip Navigation LinksHome > July 2013 - Volume 20 - Issue 4 > Ductal Carcinoma In Situ: Morphology-Based Knowledge and Mol...
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Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e3182976ed5
Review Articles

Ductal Carcinoma In Situ: Morphology-Based Knowledge and Molecular Advances

Ross, Dara S. MD; Wen, Yong Hannah MD, PhD; Brogi, Edi MD, PhD

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Abstract

Ductal carcinoma in situ (DCIS) is an established precursor of invasive breast carcinoma. Immunoperoxidase stains for selected markers can assist pathologists in the diagnosis of challenging ductal epithelial proliferations, but they cannot replace morphologic evaluation as the primary and critical assessment of this disease. Molecular studies provide further insight into how DCIS progresses to invasive carcinoma and also confirm the heterogeneity of this lesion. Morphology-based knowledge, immunohistochemistry, and molecular advances in DCIS are the subjects of this review.

Copyright © 2013 by Lippincott Williams & Wilkins

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