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Next-generation Sequencing Discoveries in Lymphoma

Slack, Graham W. MD; Gascoyne, Randy D. MD

Advances in Anatomic Pathology: March 2013 - Volume 20 - Issue 2 - p 110–116
doi: 10.1097/PAP.0b013e3182862724
Review Articles

Since the mapping of the human genome and the advent of next-generation sequencing technology thorough examination of the cancer genome has become a reality. Over the last few years several studies have used next-generation sequencing technology to investigate the genetic landscape of Hodgkin and non-Hodgkin lymphomas, identifying novel genetic mutations and gene rearrangements that have shed new light on the underlying tumor biology in these diseases as well as identifying possible targets for directed therapy. This review covers the major discoveries in lymphoma using next-generation sequencing technology.

Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada

The authors have no funding or conflicts of interest to disclose.

Reprints: Graham W. Slack, MD, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada, V5Z 4E6 (e-mail: gwslack@bccancer.bc.ca).

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