Human Correlates of Provocative Questions in Pancreatic PathologyMcDonald, Oliver G. MD, PhD; Maitra, Anirban MBBS; Hruban, Ralph H. MDAdvances in Anatomic Pathology: November 2012 - Volume 19 - Issue 6 - p 351–362 doi: 10.1097/PAP.0b013e318273f998 Review Articles Abstract Author Information Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that “genetic signals” may be more accurate than today’s multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on “the evidence derived from man.” Departments of *Pathology †Oncology ‡Institute for Genetic Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD Supported by NIH Grant P50CA062924 and the Ruth Kirschstein National Research Service Award (T32 CA067751). The authors have no conflicts of interest to disclose. Reprints: Ralph H. Hruban, MD, Department of Pathology, The Johns Hopkins Hospital, Weinberg Building Room 2242, 401 North Broadway, Baltimore, MD 21231 (e-mail: firstname.lastname@example.org). All figures can be viewed online in color at http://www.anatomicpathology.com. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.