Skip Navigation LinksHome > July 2012 - Volume 19 - Issue 4 > Liver Biopsy in Modern Clinical Practice: A Pediatric Point...
Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e31825c6a20
Review Articles

Liver Biopsy in Modern Clinical Practice: A Pediatric Point-of-View

Ovchinsky, Nadia MD, MBA*; Moreira, Roger K. MD; Lefkowitch, Jay H. MD; Lavine, Joel E. MD, PhD*

Collapse Box

Abstract

Liver biopsy remains the foundation of evaluation and management of liver disease in children, although the role of the liver biopsy is changing with development of alternative methods of diagnosis and advancement of hepatic imaging techniques. The indications for liver biopsy are evolving as current knowledge of etiologies, noninvasive biomarker alternatives, and treatment options in pediatric liver disease are expanding. The procedure can often be complicated in children by technical difficulties, cost, and smaller specimen size. Communication and partnership of clinicians with pathologists experienced in pediatric liver diseases are essential. DNA sequencing, novel imaging modalities, noninvasive biomarkers of fibrosis and apoptosis, proteomics, and genome-wide association studies offer potential alternative methods for evaluation of liver disease in children. This review presents specific indications, considerations, methods, complications, contraindications, and alternatives for pediatric liver biopsy.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.