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Thyroid Fine Needle Aspirate: A Post-Bethesda Update

Bose, Shikha MD; Walts, Ann E. MD

Advances in Anatomic Pathology: May 2012 - Volume 19 - Issue 3 - p 160–169
doi: 10.1097/PAP.0b013e3182534610
Review Articles

The Bethesda system for reporting thyroid cytopathology formulated in 2007 has standardized reporting of thyroid cytology specimens and streamlined management algorithms. Although 3 of the categories (benign, malignant, and nondiagnostic) are standardized and improved, the remaining 3 (follicular lesion of undetermined significance, follicular neoplasm, and suspicious for malignancy) remain fraught with interobserver variability and uncertainty regarding management algorithms. Recent and ongoing morphologic and molecular studies that aim to resolve these issues are summarized.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

The authors have no funding or conflicts of interest to disclose.

Reprints: Shikha Bose, MD, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd. Suite 8709, Los Angeles, CA 90048 (e-mail: boses@cshs.org).

Figure 2 can be viewed online in color at http://www.anatomicpathology.com.

© 2012 Lippincott Williams & Wilkins, Inc.