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Changing the Term “Breast Tumor Resembling the Tall Cell Variant of Papillary Thyroid Carcinoma” to “Tall Cell Variant of Papillary Breast Carcinoma”

Masood, Shahla MD; Davis, Cindy MD, MEd; Kubik, Melanie J. MD

Advances in Anatomic Pathology: March 2012 - Volume 19 - Issue 2 - p 108–110
doi: 10.1097/PAP.0b013e318249d090
Review Articles

Papillary lesions of the breast continue to be a diagnostic challenge because of the wide morphologic spectrum that may be encountered in these lesions. A rare entity termed “breast tumor resembling the tall cell variant of papillary thyroid carcinoma” is considered to be a subtype of papillary carcinoma of the breast. It is characterized by distinct morphologic features, setting it apart from typical papillary carcinoma of the breast. Its resemblance to papillary thyroid carcinoma in conjunction with the established terminology may cause confusion, resulting in unnecessary ancillary studies to exclude the association of this lesion with papillary thyroid carcinoma. As immunohistochemical and molecular studies have shown no evidence to support any association between this entity and papillary thyroid carcinoma, we propose to change the current terminology of “breast tumor resembling the tall cell variant of papillary thyroid carcinoma” to the term “tall cell variant of papillary breast carcinoma.”

Department of Pathology and Laboratory Medicine, College of Medicine-Jacksonville, University of Florida, Jacksonville, FL

The authors have no funding or conflicts of interest to disclose.

Reprints: Shahla Masood, MD, Department of Pathology and Laboratory Medicine, College of Medicine-Jacksonville, University of Florida, 655W, 8th Street, Jacksonville, FL 32209 (e-mail: shahla.masood@jax.ufl.edu).

© 2012 Lippincott Williams & Wilkins, Inc.