Skip Navigation LinksHome > January 2012 - Volume 19 - Issue 1 > Pediatric Fibroblastic and Myofibroblastic Lesions
Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e31823d76ed
Review Articles

Pediatric Fibroblastic and Myofibroblastic Lesions

Thway, Khin MBBS, BSc, FRCPath*; Fisher, Cyril MD, DSc, FRCPath*; Sebire, Neil J. MD, FRCPath

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Abstract

Fibrous lesions of infancy and childhood are a heterogeneous group of entities composed predominantly of fibroblasts and myofibroblasts, ranging from reactive lesions to neoplasms with a range of malignant potential. Although rare, their correct recognition by histopathology is important clinically as they exhibit a wide range of behaviors and may be associated with distinct underlying syndromes. Contributions from molecular diagnostics have enabled more accurate diagnosis, and have changed our concepts of some tumor types. In this review, we discuss the clinicopathologic spectrum of fibroblastic and myofibroblastic lesions of childhood and adolescence.

© 2012 Lippincott Williams & Wilkins, Inc.

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