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Napsin A Expression in Lung and Kidney Neoplasia: A Review and Update

Ordóñez, Nelson G. MD

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e31823e472e
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Napsin A is an aspartic protease present in the epithelial cells of the lung and kidney. Recent studies have shown that, in lung tumors, napsin A expression is restricted to lung adenocarcinomas, whereas among renal tumors, it is frequently expressed in renal cell carcinomas, especially the papillary and clear cell subtypes. Owing to its restricted expression, napsin A is a useful marker that can assist in the diagnosis of both lung adenocarcinomas and renal cell carcinomas.

Author Information

University of Texas, M.D. Anderson Cancer Center, Houston, TX

The author has no funding or conflicts of interest to disclose.

Reprints: Nelson G. Ordóñez, MD, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.