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Acral Soft Tissue Tumors: A Review

Mahajan, Dipti MD; Billings, Steven D. MD; Goldblum, John R. MD

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e31820ca7a6
Review Articles

Acral soft tissue tumors may present significant diagnostic challenges both for the pathologist and the clinician. This review discusses the most common benign and malignant entities that characteristically present in an acral location. Clinical, histologic, and immunohistochemical features are discussed along with prognosis and differential diagnosis.

Author Information

Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH

The authors do not have any source of support or disclosure of funding.

Reprints: John R. Goldblum, MD, Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195 (e-mail: figures can be viewed online in color at

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