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Benign Cartilaginous Tumors of Bone: From Morphology to Somatic and Germ-line Genetics

Romeo, Salvatore MD*; Hogendoorn, Pancras C.W. MD, PhD; Dei Tos, Angelo Paolo MD*

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e3181b506a1
Review Articles
Abstract

Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondroma as well as rare tumors such as chondroblastoma and chondromyxoid fibroma. Several benign and malignant tumors may mimic benign cartilaginous tumors of bones. We reviewed the main morphologic features and the differential diagnosis is discussed. The genetics of these tumors is intriguing ranging from single gene event (ie, EXT mutation in multiple osteochondromas) to heterogeneous rearrangements with no recurrent involved chromosomal regions such as in chondroblastoma. The main genetic findings are hereby reviewed.

Author Information

*Department of Pathology, Treviso Regional Hospital, Treviso, Italy

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Reprints: Angelo Paolo Dei Tos, MD, Department of Pathology, Regional Hospital of Treviso, Piazza Ospedale 1, 31100 Treviso, Italy (e-mail: apdeitos@ulss.tv.it).

The authors are partners within EuroBoNeT, a European Community granted network of excellence for studying pathology and genetics of bone tumors.

© 2009 Lippincott Williams & Wilkins, Inc.