Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondroma as well as rare tumors such as chondroblastoma and chondromyxoid fibroma. Several benign and malignant tumors may mimic benign cartilaginous tumors of bones. We reviewed the main morphologic features and the differential diagnosis is discussed. The genetics of these tumors is intriguing ranging from single gene event (ie, EXT mutation in multiple osteochondromas) to heterogeneous rearrangements with no recurrent involved chromosomal regions such as in chondroblastoma. The main genetic findings are hereby reviewed.
*Department of Pathology, Treviso Regional Hospital, Treviso, Italy
†Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Reprints: Angelo Paolo Dei Tos, MD, Department of Pathology, Regional Hospital of Treviso, Piazza Ospedale 1, 31100 Treviso, Italy (e-mail: firstname.lastname@example.org).
The authors are partners within EuroBoNeT, a European Community granted network of excellence for studying pathology and genetics of bone tumors.