Skip Navigation LinksHome > May 2009 - Volume 16 - Issue 3 > Merkel Cell Carcinoma: Review
Text sizing:
A
A
A
Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e3181a12f5a
Review Articles

Merkel Cell Carcinoma: Review

Pulitzer, Melissa P. MD; Amin, Bijal D. MD; Busam, Klaus J. MD

Collapse Box

Abstract

Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients. The recent identification of a novel polyomavirus associated with the tumor has stimulated renewed interest in its pathogenesis. MCC tends to show classic histologic features of a neuroendocrine carcinoma and is often positive for CK20, but nonclassic cytologic findings and unusual immunophenotypes may be observed and can lead to a diagnostic confusion. MCC needs to be distinguished from other primary cutaneous tumors with a small cell appearance and metastatic tumors. Surgical excision is the treatment of choice, but radiation therapy has also found to be effective. Sentinel lymph node biopsy has become an integral part of the staging of patients with MCC.

© 2009 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.