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Epstein-Barr Virus in Lymphoproliferative Processes: An Update for the Diagnostic Pathologist

Ng, Siok-Bian MBBS*; Khoury, Joseph D. MD

Advances in Anatomic Pathology:
doi: 10.1097/PAP.0b013e3181916029
Review Articles

The Epstein-Barr virus is an orally transmitted herpesvirus that is widespread in human populations and exhibits marked B-cell tropism. It is associated with more human neoplasms than any other known virus, and its role in the pathogenesis of such neoplasms has been the subject of intense investigation. This review presents an overview and update of the biology of Epstein-Barr virus and the diagnostic features of lymphoproliferative disorders associated with this intriguing human pathogen.

Author Information

*Department of Pathology, National University of Singapore and National University Hospital, Singapore

Department of Pathology, Nevada Cancer Institute, Las Vegas, NV

Joseph D. Khoury is also Associate Director and Medical Director of Hematopathology at Quest Diagnostics, Las Vegas, NV.

Siok-Bian Ng and Joseph D. Khoury have no financial conflicts of interests to declare.

Reprints: Joseph D. Khoury, MD, Department of Pathology, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135 (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.