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Immunohistochemistry of INI1 Expression: A New Tool for Old Challenges in CNS and Soft Tissue Pathology

Judkins, Alexander R. MD

Advances in Anatomic Pathology: September 2007 - Volume 14 - Issue 5 - p 335-339
doi: 10.1097/PAP.0b013e3180ca8b08
New Antibodies

Immunohistochemical staining for INI1 (BAF47) expression has been recently described. Loss of expression of INI1 as detected by immunohistochemical staining correlates with deletion and mutations of the INI1 gene in patients with malignant rhabdoid tumors and central nervous system atypical teratoid/rhabdoid tumors and as such is a sensitive and specific marker for these tumors. Loss of INI1 expression may rarely be encountered in other tumor types. This article reviews the utility of immunohistochemical staining for INI1 expression.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA

Reprints: Alexander R. Judkins, MD, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, 802G Abramson Research Center, 3615 Civic Center Blvd, Philadelphia, PA 19104 (e-mail: judkins@mail.med.upenn.edu).

Received for publication April 4, 2007; accepted May 1, 2007

© 2007 Lippincott Williams & Wilkins, Inc.