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The Diagnosis of Malignancy in Effusion Cytology: A Pattern Recognition Approach

Pereira, Telma C. MD*; Saad, Reda S. MD, PhD* †; Liu, Yulin MD, PhD* †; Silverman, Jan F. MD* †

Advances in Anatomic Pathology:
Review Articles

This review presents a pattern recognition approach for the diagnosis of malignant effusions. The cytomorphologic features of reactive mesothelial proliferation, mesothelioma and metastatic carcinoma are presented. In addition, the role of ancillary studies in challenging cases and the importance of integrating clinical findings are stressed. An algorithmic approach to the workup of serous effusions as well as pitfalls for false-positive diagnosis are discussed.

Author Information

*Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA

Drexel University College of Medicine

Reprints: Telma C. Pereira, MD, Department of Pathology, Allegheny General Hospital, 320 E North Avenue, Pittsburgh, PA 15212 (e-mail:

Received for publication April 13, 2006; accepted May 25, 2006

© 2006 Lippincott Williams & Wilkins, Inc.