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Clear Cell Hidradenoma of the Skin—A Third Tumor Type With a t(11;19)-Associated TORC1-MAML2 Gene Fusion: Genes Chromosomes Cancer. 2005;43:202–205

El-Naggar, Adel K. MD, PhD

Advances in Anatomic Pathology: March 2006 - Volume 13 - Issue 2 - p 80-82
doi: 10.1097/01.pap.0000213000.79866.bd
Brief Commentary

Recent cloning of the MEC-1/MAML2 gene, resulting from translocations of chromosomes 11q21 and 19p23, has for the first time linked specific genetic alterations to the development of specific salivary gland tumors. Such a unique finding in an epithelial neoplasm opens new horizons in understanding the evolution of these tumors and allows for the development of therapeutic modalities that target these events.

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Reprints: Adel K. El-Naggar, MD, PhD, Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 085, Houston, TX 77030 (e-mail: anaggar@mdanderson.org)

Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.