Recent cloning of the MEC-1/MAML2 gene, resulting from translocations of chromosomes 11q21 and 19p23, has for the first time linked specific genetic alterations to the development of specific salivary gland tumors. Such a unique finding in an epithelial neoplasm opens new horizons in understanding the evolution of these tumors and allows for the development of therapeutic modalities that target these events.
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
Reprints: Adel K. El-Naggar, MD, PhD, Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 085, Houston, TX 77030 (e-mail: email@example.com)