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Advances in Anatomic Pathology:
doi: 10.1097/01.pap.0000213000.79866.bd
Brief Commentary

Clear Cell Hidradenoma of the Skin—A Third Tumor Type With a t(11;19)-Associated TORC1-MAML2 Gene Fusion: Genes Chromosomes Cancer. 2005;43:202–205

El-Naggar, Adel K. MD, PhD

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Abstract

Recent cloning of the MEC-1/MAML2 gene, resulting from translocations of chromosomes 11q21 and 19p23, has for the first time linked specific genetic alterations to the development of specific salivary gland tumors. Such a unique finding in an epithelial neoplasm opens new horizons in understanding the evolution of these tumors and allows for the development of therapeutic modalities that target these events.

© 2006 Lippincott Williams & Wilkins, Inc.

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