Skip Navigation LinksHome > March 2014 - Volume 347 - Issue 3 > Pentraxin 3 Production in the Adipose Tissue and the Skeleta...
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e31828341af
Basic Investigation

Pentraxin 3 Production in the Adipose Tissue and the Skeletal Muscle in Diabetic-Obese Mice

Miyaki, Asako PhD; Choi, Youngju PhD; Maeda, Seiji PhD

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Abstract

Inflammation has been shown to promote obesity-induced insulin resistance. Although pentraxin (PTX) 3 is known as an anti-inflammatory factor, the effect of PTX3 on insulin sensitivity has not yet been elucidated. The aim of this study is to investigate a part of the role of PTX3 on insulin sensitivity. The authors studied the PTX3 and glucose transport protein expression levels in epididymal adipose tissue and soleus muscles of male diabetic-obese [Tsumura Suzuki obese-diabetic (TSOD)] and lean control mice. The levels of PTX3 in both skeletal muscle and adipose tissue were significantly lower in TSOD mice than in controls, and there was a significant positive correlation between them. They observed a significant positive correlation between PTX3 and glucose transport protein 4 levels in skeletal muscle. This study suggests that PTX3 may play a part of role as promoting insulin sensitivity of skeletal muscle in TSOD mice.

Copyright © 2013 by the Southern Society for Clinical Investigation

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