Skip Navigation LinksHome > August 2010 - Volume 340 - Issue 2 > Positron Emission Tomography With 18F-Fluorodeoxyglucose Is...
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e3181e20a20
Case Report

Positron Emission Tomography With 18F-Fluorodeoxyglucose Is a Useful Tool for the Diagnosis of Pheochromocytomas Without Distant Metastasis, Where Malignancy Is Suspected on the Basis of Histopathologic Analysis.

Kikuchi, Fumi MD; Imachi, Hitomi MD, PhD; Murao, Koji MD, PhD; Ohyama, Tomoyo MD, PhD; Miyai, Yumi MD; Kushida, Yoshio MD, PhD; Haba, Reiji MD, PhD; Kakehi, Yoshiyuki MD, PhD; Ishida, Toshihiko MD, PhD

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Abstract

A 69-year-old woman, who had been undergoing treatment for hypertension, was admitted to the hospital for the evaluation of a tumor in the right adrenal gland and of episodic hypertension. She was diagnosed with pheochromocytoma on the basis of elevated urine catecholamine and metabolite concentrations and positron emission tomography (PET) results; however, the results of 131I-metaiodobenzylguanidine (131I-MIBG) scintigraphy were negative. The patient underwent laparoscopic right adrenalectomy. Malignancy was suspected on the basis of histopathologic studies. After surgery, the elevated catecholamine and metabolite concentrations and the blood pressure returned to normal; furthermore, the symptoms, including severe headache, reduced. The authors report a case of pheochromocytoma that was suspected to be malignant on the basis of histopathologic analysis and was detected by 18F-fluorodeoxyglucose (FDG)-PET but not by MIBG. Thus, FDG-PET may be a prognostic marker for malignant pheochromocytomas with or without metastasis.

© Copyright 2010 Southern Society for Clinical Investigation

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