Skip Navigation LinksHome > August 2010 - Volume 340 - Issue 2 > Managing Type 2 Diabetes in the Primary Care Setting: Beyond...
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e3181d64344
Review Article

Managing Type 2 Diabetes in the Primary Care Setting: Beyond Glucocentricity.

Kuritzky, Louis MD

Collapse Box


Successful management of type 2 diabetes mellitus (T2DM) requires attention to additional conditions often associated with hyperglycemia including overweight or obesity, dyslipidemia and hypertension, as each has some relationship with microvascular or macrovascular complications. Because control of cardiovascular risk factors is as important as glucose control in T2DM, these risk factors need to be addressed, and it is critical that antidiabetes medications do not exacerbate these risk factors. A patient-centered approach to treatment in which clinicians maximize patient involvement in the selection of antidiabetes therapy may lead to increased adherence and improved clinical outcomes. The incretin hormones, which include glucagon-like peptide–1 (GLP-1), are involved in glucoregulation and have become an important focus of T2DM research and treatment. Incretin-based therapies, such as the glucagon-like peptide-1 receptor agonists and the dipeptidyl peptidase–IV inhibitors, have shown beneficial effects on hyperglycemia, weight, blood pressure and lipids with a low incidence of hypoglycemia.

© Copyright 2010 Southern Society for Clinical Investigation


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.