Skip Navigation LinksHome > August 2010 - Volume 340 - Issue 2 > Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hy...
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e3181e52de9
Grand Rounds Contributor: Trainee Research Reports

Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension.

LeBlanc, Ryan M. BS; Navar, L. Gabriel PhD; Botros, Fady T. PhD

Section Editor(s): Navar, L. Gabriel PhD; Gööz, Monika MD, PhD

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Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n = 4) and Ang II + bilirubin (n = 4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3 mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7 mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9 mm Hg (P < 0.05) in the Ang II + bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II + bilirubin group (32.9 ± 9.7 mg/d versus 81.4 ± 22.8 mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.

© Copyright 2010 Southern Society for Clinical Investigation


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