Home Current Issue Previous Issues Published Ahead-of-Print Collections For Authors Journal Info
Skip Navigation LinksHome > August 2010 - Volume 340 - Issue 2 > Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hy...
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e3181e52de9
Grand Rounds Contributor: Trainee Research Reports

Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension

LeBlanc, Ryan M. BS; Navar, L. Gabriel PhD; Botros, Fady T. PhD

Section Editor(s): Navar, L. Gabriel PhD; Gööz, Monika MD, PhD

Collapse Box

Abstract

Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n = 4) and Ang II + bilirubin (n = 4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3 mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7 mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9 mm Hg (P < 0.05) in the Ang II + bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II + bilirubin group (32.9 ± 9.7 mg/d versus 81.4 ± 22.8 mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.

© Copyright 2010 Southern Society for Clinical Investigation

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.