Skip Navigation LinksHome > July 2009 - Volume 338 - Issue 1 > Nutrient Dyshomeostasis in Congestive Heart Failure.
American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e3181aaee63
Symposium Articles

Nutrient Dyshomeostasis in Congestive Heart Failure.

Kamalov, German MD, PhD; Holewinski, Joshua P. BS; Bhattacharya, Syamal K. PhD; Ahokas, Robert A. PhD; Sun, Yao MD, PhD; Gerling, Ivan C. PhD; Weber, Karl T. MD

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Abstract

The clinical syndrome congestive heart failure (CHF) has its origins rooted in a salt-avid state mediated largely by effector hormones of the renin-angiotensin-aldosterone system. In recent years, this cardiorenal perspective of CHF has taken on a broader perspective. One which focuses on a progressive systemic illness, whose major features include the presence of oxidative stress in diverse tissues and elevated circulating levels of proinflammatory cytokines coupled with a wasting of soft tissues and bone. Experimental studies, which simulate chronic renin-angiotensin-aldosterone system activation, and translational studies in patients with salt avidity having decompensated biventricular failure with hepatic and splanchnic congestion have forged a broader understanding of this illness and the important contribution of a dyshomeostasis of Ca2+, Mg2+, Zn2+, Se2+, and vitamins D, B12, and B1. Herein, we review biomarkers indicative of the nutrient imbalance found in CHF and raise the question of a need for a polynutrient supplement in the overall management of CHF.

© Copyright 2009 Southern Society for Clinical Investigation

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