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American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e31819c1027
Clinical Investigation

Influence of Intravenous Propofol Sedation on Anorectal Manometry in Healthy Adults

Liu, Tso-Tsai MD; Yi, Chih-Hsun MD; Chen, Chien-Lin MD; Liu, Hsu-Tang MD; Chen, Tsung-Ying

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Abstract

Background: We aimed to determine whether conscious sedation by propofol could affect anorectal manometry.

Methods: Eighteen healthy subjects underwent anorectal manometry at baseline and during conscious sedation by propofol. Sedation levels were monitored by auditory-evoked potentials.

Results: All subjects showed a normal rectoanal inhibitory reflex (RAIR) before conscious sedation. During conscious sedation, the resting anal sphincter pressure was significantly lower compared with that before conscious sedation (15 ± 2 versus 42 ± 4 mm Hg, P < 0.001). RAIR was present in all subjects during conscious sedation. There was no difference in threshold volume inducing RAIR before and during conscious sedation (P = NS). The level of auditory-evoked potentials did not correlate well with any of the anorectal parameters.

Conclusions: Propofol significantly reduces the resting anal sphincter pressure without affecting RAIR. The inability to obtain useful data in anorectal sensation and sphincter pressure might limit the utility of propofol as a sedation agent for performing anorectal manometry.

© Copyright 2009 Southern Society for Clinical Investigation

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