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American Journal of the Medical Sciences:
doi: 10.1097/MAJ.0b013e31818eb2a2
Clinical Investigation

Polymorphisms of MMP-2 Gene are Associated With Systolic Heart Failure Risk in Han Chinese

Hua, Yihong MD; Song, Li MD; Wu, Naqiong MD; Lu, Xiangfeng PhD; Meng, Xianmin MD; Gu, Dongfeng MD, PhD; Yang, Yuejin MD, PhD

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Abstract

Background: Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for protein degradation. MMP-2 has been demonstrated to play a pivotal role in myocardial remodeling process that occurs in congestive heart failure (HF). We hypothesized that MMP-2 genetic variations could be associated with systolic HF risk.

Methods: To test the association of single nucleotide polymorphisms of MMP-2 with systolic HF risk, we performed a hospital-based, case-control study of 605 patients with systolic HF and 689 controls without HF. Three single nucleotide polymorphisms of MMP-2 (rs243864, rs243866, and rs17859821) were genotyped by restriction fragment length polymorphism methods.

Results: The genotype frequencies of MMP-2 rs243866 AA and AG in the control group were significantly higher than that in the case group (24.7% versus 17.9%, P < 0.01). Compared with the GG homozygotes, MMP-2 rs243866 A allele carriers had a significantly lower risk of systolic HF (adjusted OR 0.69, 95% CI 0.49-0.98; P = 0.035). Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).

Conclusion: The findings of the current study suggest that MMP-2 rs243866 A allele was associated with lower risk of systolic HF in Han Chinese.

© Copyright 2009 Southern Society for Clinical Investigation

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