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Acute Necrotizing Large Vessel Arteritis in a Newborn: A Case Report and Review of the Literature

Hejazi, Arya MD; Hosseini, Marzieh MD; Bahrani, Mohammadreza MD

American Journal of Forensic Medicine & Pathology:
doi: 10.1097/PAF.0b013e31828d69da
Case Reports

Abstract: Acute arteritis of the aorta and the main pulmonary arteries is unusual in a newborn. This type of vasculitis should be described as a separate entity. There are many differences between this entity and polyarteritis nodosa or Takayasu disease. Moreover, neither Takayasu disease nor polyarteritis nodosa and other forms of classic primary large vessels vasculitis have been reported in a neonate until now. The presence of chronic inflammation, fibrosis, and calcification would suggest that this process had been present before birth.

We report a 27-day-old newborn with acute necrotizing aortitis. The feature of this entity is not those of any of the classic entities described in infants or children.

Author Information

From the Department of Pathology Laboratory, Fars Legal Medicine Research Center, Shiraz, Iran.

Manuscript received August 17, 2012; accepted December 5, 2012.

The authors report no conflicts of interest.

Reprints: Marzieh Hosseini, MD, Department of Pathology Laboratory, Fars Legal Medicine Research Center, PO Box 71345-1864, Shiraz, Iran. E-mail:

© 2013 by Lippincott Williams & Wilkins.