Skip Navigation LinksHome > September 2012 - Volume 33 - Issue 3 > Acute Ibuprofen Intoxication: Report on a Case and Review of...
American Journal of Forensic Medicine & Pathology:
doi: 10.1097/PAF.0b013e318253d6ff
Case Reports

Acute Ibuprofen Intoxication: Report on a Case and Review of the Literature

Lodise, Maria MD*; De-Giorgio, Fabio MD, PhD*; Rossi, Riccardo MD*; d’Aloja, Ernesto MD, PhD; Fucci, Nadia PhD*

Collapse Box


Abstract: A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.

Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.

© 2012 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.