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Rupture of Splenic Artery Aneurysm in Pregnancy: A Review of the Literature and Report of Two Cases

He, Miao-Xia MD*; Zheng, Jian-Ming MD*; Zhang, Shu-hui MD; Wang, Jian-Jun BS*; Liu, Wei-Qiang BS*; Zhu, Ming-Hua MD*

The American Journal of Forensic Medicine and Pathology: March 2010 - Volume 31 - Issue 1 - p 92-94
doi: 10.1097/PAF.0b013e3181c65da2
Case Report

Background: Splenic artery aneurysms are an uncommon form of vascular disease, which have a significant potential for rupture, most commonly associated with pregnancy, typically presents as sudden, unexpected death. As a consequence, the initial recognition and diagnosis of splenic artery aneurysm rupture take place only at autopsy.

Clinical Cases: This report presents 2 cases of sudden death resulting from splenic artery aneurysm in a pregnant woman and a postpartum woman, respectively. The former splenic artery aneurysm were measuring 1 cm in diameter and the latter splenic artery aneurysm 5.5 × 5 × 2 cm in size. Histologic examination of the both vessels wall showed severe morphologic changes of degeneration together with an attenuation of arterial internal elastica.

Conclusions: To our knowledge, splenic artery aneurysm in pregnant woman is unusual vital disease. It is essential that obstetricians are alert to the prodromal and catastrophic symptoms of splenic artery aneurysm. Early recognition and prompt management, including early resected electively, are vital to the survival of both mother and fetus.

From the *Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China; and †Department of Pathology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Manuscript received May 13, 2008; accepted July 19, 2008.

Reprints: Jian-Ming Zheng, PhD, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. E-mail:

© 2010 Lippincott Williams & Wilkins, Inc.