Skip Navigation LinksHome > March 2010 - Volume 31 - Issue 1 > Accidental Intrathecal Administration of Vincristine
American Journal of Forensic Medicine & Pathology:
doi: 10.1097/PAF.0b013e3181c21c10
Case Report

Accidental Intrathecal Administration of Vincristine

D'Addario, Adriana MD*; Galuppo, Juan MD†; Navari, Carlos MD*; Schultz, Marcelo HT§; Cuello, Nélida HT*; Troncoso, Juan C. MD‡; Riudavets, Miguel Angel MD*§

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Abstract

We describe a case of accidental intrathecal administration of vincristine in a 33-year-old man with clinical diagnosis of acute lymphocytic leukemia. The patient died 20 days after receiving the drug. Clinically, the patient developed acute ascending paralysis with motor and sensory dysfunctions, and respiratory failure. Neuropathological investigation revealed lesions in spinal cord, roots, and cerebellum characterized by rarefaction of the neuropil, axonal, and myelin degeneration, accompanied by macrophagic infiltration.

© 2010 Lippincott Williams & Wilkins, Inc.

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