Skip Navigation LinksHome > December 1997 - Volume 18 - Issue 4 > Pathogenicity of Carbon Monoxide
American Journal of Forensic Medicine & Pathology:
Articles

Pathogenicity of Carbon Monoxide

Jaffe, Frederick A. M.D. M.Sc. F.R.C.P.(C.)

Collapse Box

Abstract

The effects of carbon monoxide, one of the most commonly encountered toxic agents in forensic practice, have been known for a long time, but the nature of its bonding to the heme prosthetic group of hemoproteins has only recently been elucidated. In addition to reducing the oxygen capacity of the blood and the consequent systemic hypoxia, carbon monoxide interferes with the dissociation of oxyhemoglobin and the removal of carbon dioxide. Carbon monoxide also produces a direct cytotoxic effect by inactivating some intracellular respiratory enzymes, but the relative importance of these various mechanisms often remains uncertain, particularly with regard to the lesions in the brain and myocardium.

© Lippincott-Raven Publishers.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.